West Main Street Historic District, or West Main Street District or variations, may refer to:
United States (by state then city) Georgia West Main Street Commercial Historic District (Statesboro, Georgia), listed on the National Register of Historic Places (NRHP) in Bulloch County
Kentucky West Main Street Historic District (Georgetown, Kentucky), listed on the NRHP in Scott County, Kentucky West Main Street District (Greenup, Kentucky), listed on the National Register of Historic Places in Greenup County, Kentucky West Main Street Historic District (Louisville, Kentucky), NRHP-listed
Massachusetts West Main Street Historic District (Marlborough, Massachusetts), NRHP-listed in Middlesex County West Main Street Historic District (Westborough, Massachusetts), NRHP-listed in Worcester County
North Carolina West Main Street Historic District (Forest City, North Carolina), NRHP-listed in Rutherford County West Main Street Historic District (Lincolnton, North Carolina), NRHP-listed in Lincoln County
Ohio West Main Street District (Kent, Ohio), NRHP-listed in Portage County Lancaster West Main Street Historic District, Lancaster, Ohio, listed on the NRHP in Fairfield County West Main Street District (Norwalk, Ohio), listed on the National Register of Historic Places in Huron County
South Carolina West Main Street Historic District (Chesterfield, South Carolina), NRHP-listed in Chesterfield County
Virginia West Main Street Historic District (Charlottesville, Virginia), NRHP-listed
Wisconsin West Main Street Historic District (Oconto, Wisconsin), NRHP-listed in Oconto County West Main Street Historic District (Platteville, Wisconsin), listed on the NRHP in Grant County
See also Madison Square–West Main Street Historic District, NRHP-listed in Monroe County, New York West Main Street–West James Street Historic District, NRHP-listed in Otsego County, New York Main Street Historic District (disambiguation) North Main Street Historic District (disambiguation) South Main Street Historic District (disambiguation) East Main Street Historic District (disambiguation)