Desfontaines is a surname. Notable people with the surname include:
François-Georges Fouques Deshayes (known as Desfontaines-Lavallée or Desfontaines, 1733-1825), French writer and playwright. Henri Desfontaines (1876-1931), French film director, actor and scriptwriter Jean Desfontaines (c. 1658–1752), French Baroque composer Pierre Desfontaines (1685-1745), French journalist René Louiche Desfontaines (1750-1833), French botanist
See also
Deffontaines