Manuel Uribe may refer to:
Manuel Uribe Ángel (1822–1914), Colombian academic and physician, governor of Antioquia, first curator of the Museum of Antioquia Manuel Uribe Troncoso (1867–1959), Mexican ophthalmologist and founding member of the Colegio Nacional Manuel Uribe Barra (1895–1970), Chilean politician Manuel Uribe (footballer) (born 1948), Peruvian goalkeeper Manuel Uribe (obese man) (1965–2014), Mexican man, one of the heaviest people in medical history
See also Manuel Oribe (1792–1857), Uruguayan politician