The surname Guillemin can refer to:
Amédée Guillemin (1826–1893), French science author and journalist Amédée Henri Guillemin (1860–1941), French general Ernst Guillemin (1898–1970), American electrical engineer and computer scientist Francisco Romano Guillemin (1884–1950), Mexican painter Jean Baptiste Antoine Guillemin (1796–1842), French botanist Jean-Philippe Guillemin (born 1972), French computer programmer and musician Jeanne Guillemin (1943–2019), American medical anthropologist Karen Guillemin, American microbiologist Philippe François Zéphirin Guillemin (1814–1886), French Roman Catholic bishop Robert Charles Guillemin (1939–2015), American ephemeral artist known as Sidewalk Sam Roger Guillemin (1924–2024), French-American neurologist and Nobel laureate in medicine Victor Guillemin (born 1937), American mathematician, father of Karen
See also Guillemin coupling Guillemain