Schiller–Duval body is a cellular structure seen by microscope in endodermal sinus tumors (yolk sac tumors) which are the most common testicular cancer in children. Schiller-Duval bodies are present in approximately 50% of these tumors, and if found are pathognomonic.Kumar, Abbas, Fausto. Pathologic Basis of Disease, 7th edition. Philadelphia; Elsevier-Saunders, 2005. 1042. They are named for Mathias-Marie Duval and Walter Schiller "Schiller–Duval bodies" at whonamedit.com who described them in the late nineteenth century.Duval M. Le placenta des rongeurs. Journal de l'anatomie et de la physiologie normales et pathologiques de l'homme et des animaux, Paris, 1891, 27: 24–73, 344–395, 513–612.
Schiller–Duval bodies are said to resemble a glomerulus.Kumar, Abbas, Fausto. Pathologic Basis of Disease, 7th edition. Philadelphia; Elsevier-Saunders, 2005. 1101. They have a mesodermal core with a central capillary, all lined by flattened layers of both visceral and parietal cells. Immunofluorescent stain may show eosinophilic hyalin-like globules both inside and outside the cytoplasm that contain AFP and alpha 1-antitrypsin.
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