C53 or C-53 may refer to: , an Admirable-class minesweeper of the Mexican Navy Caldwell 53, a lenticular galaxy CDK5RAP3, a gene encoding CDK5 regulatory subunit-associated protein 3 Cervical cancer Douglas C-53 Skytrooper, an American military aircraft GER Class C53, a British tram engine class , a Minotaur-class light cruiser of the Royal Canadian Navy JNR Class C53, a Japanese steam locomotive Succession to the Throne Act, 2013, Bill C-53 of the Parliament of Canada