Casilla is a Spanish surname, and may refer to:
Alexi Casilla (born 1984), Dominican Major League Baseball infielder José Antonio Casilla (born 1979), Spanish volleyball player Kiko Casilla (born 1986), Spanish footballer Robert Casilla (born 1959), American artist and illustrator Santiago Casilla (born 1980), Dominican Major League Baseball relief pitcher
See also Pabellón Municipal de Deportes La Casilla, 5000-seat arena in Bilbao, Spain