John Bryson (1943–2025) was an American businessman and 37th United States Secretary of Commerce.

John Bryson may also refer to:

John Bryson (mayor) (1819–1907), American politician, 19th mayor of Los Angeles, California John Bryson (author) (1935–2022), Australian author and former lawyer John Bryson (Canadian politician) (1849–1896), Canadian lumberman, farmer, and politician from Quebec John Bryson (RAF officer) (1913?–1940), Canadian fighter pilot

See also John Bryson Chane (born 1944), Episcopal bishop of Washington