Mahaprabhu () is a Sanskrit-language honorific. It may refer to:
Jagannath, a Hindu deity Vallabha (1479–1531), founder of the Pushtimarg sect Chaitanya Mahaprabhu (1486–1534), founder of the Bengali Gaudiya Vaishnavite school of Hinduism Hith Harivansh Mahaprabhu (1509–1552), founder of the Radha Vallabh Sampradaya Mahāprabhu, chief god of the Bonda people of Orissa, India Mahaprabhu (film), a 1996 Indian Tamil-language masala film