Dichloropane ((−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 3.13, 18, and 0.79 nM, respectively. In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine. It has been reported as a designer drug, first identified in 2016 in both Sweden and Slovenia.Sorribes-Soriano A, Monedero A, Esteve-Turrillas FA, Armenta S. Determination of the new psychoactive substance dichloropane in saliva by microextraction by packed sorbent - Ion mobility spectrometry. J Chromatogr A. 2019 Oct 11;1603:61-66.
Methylecgonidine is the direct precursor to this compound.
Trans -CO2Me group The thermodynamic isomer with a trans -CO2Me group is still active. This isomer was used by Neurosearch to make three different phenyltropanes which were tested in clinical trials.
Tesofensine Brasofensine NS-2359 (GSK-372,475)
See also 3,4-DCMP O-2390 List of cocaine analogues List of phenyltropanes
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