Vandenbussche is a surname. Notable people with the surname include:
Bram Vandenbussche (born 1981), Belgian footballer Brian Vandenbussche (born 1981), Belgian footballer Hanna Vandenbussche (born 1987), Belgian athlete Jordi van den Bussche (also known as Kwebbelkop), Dutch YouTuber Ryan VandenBussche (born 1973), Canadian ice hockey player