Sixth Street Historic District may refer to:
in the United States (by state) Sixth Street Historic District (Grandin, Missouri) Sixth Street Historic District (Portsmouth, Ohio), listed on the NRHP in Ohio Sixth Street Historic District (Austin, Texas) Sixth Street Historic District (Hudson, Wisconsin), listed on the NRHP in Wisconsin
Douglas-Sixth Street Historic District Historic Sixth Street Business District South Sixth Street Historic District U.S. Route 66-Sixth Street Historic District, Amarillo, TX, listed on the NRHP in Texas West Fifth Street-West Sixth Street Historic District West Sixth Street and Mayes Place Historic District, Columbia, TN, listed on the NRHP in Tennessee West Sixth Street Historic District