Epigenes may refer to:
Epigenes of Athens, c. 4th century BC ancient Greek comic poet Epigenes of Byzantium (died c. 200 BC), ancient Greek astrologer Epigenes of Sicyon, 4th century BC ancient Greek tragedist Epigenes, son of Antiphon, a disciple of Socrates Epigenes (crater), a lunar crater named after the astrologer
See also Epigenesis (disambiguation)