George Holmes may refer to:
Academics George Holmes (archivist) (1662–1749), English archivist; deputy Keeper of Records in the Tower of London George Frederick Holmes (1820–1897), American university professor and administrator George Holmes (historian) (1927–2009), Welsh professor of medieval history at the University of Oxford George Holmes (vice-chancellor) (born 1961), British academic administrator; vice-chancellor of the University of Bolton
Arts and entertainment George Holmes (musician) (c.1680–1720), English organist George Augustus Holmes (1826–1911), English painter George Holmes (actor) (1918–1985), American film and television actor
Others George Bax Holmes (1803–1887), English fossil collector George Holmes (bishop) (1858–1912), English-born Canadian Bishop of Athabasca George Holmes (footballer) (1892–?), English soccer player George H. Holmes (1898–1965), American airman; last enlisted pilot in the USAF George Holmes (civil servant) (1926–2025), British forester and public official George M. Holmes (1929–2009), American politician in the North Carolina General Assembly George Holmes (rugby union) (1893–1928), Irish rugby union player