Afinogenov is a Russian surname. Notable people with the surname include:
Inna Afinogenova (born 1989), a Russian journalist Alexander Afinogenov (1904–1941), a Russian playwright Denis Afinogenov (born 1974), a Russian ice hockey player Ekaterina Afinogenova (born 1987), a Russian tennis player, sister of Maxim Maxim Afinogenov (born 1979), a Russian ice hockey player, brother of Ekaterina
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