William Willis may refer to:
Politicians William Willis (Maine politician) (1794–1870), American politician and historian, mayor of Portland, Maine, 1857 William Willis Garth (1828–1912), American politician William Willis (British politician) (1835–1911), British politician, MP for Colchester 1880–1885 William Jarvis Willis (1840–1884), New Zealand politician William Nicholas Willis (1858–1922), Australian politician
Others William Downes Willis (1790–1871), British clergyman, theologian and author William Willis (physician) (1837–1894), British physician William Willis (inventor) (1841–1923), British inventor William Willis (sailor) (1893–1968), rafter and adventurer William Hailey Willis (1916–2000), American classicist William S. Willis (1921–1983), ethnohistorian and pioneer in African American anthropology William Willis (artist) (born 1943), American artist
See also Bill Willis (1921–2007), American football player