Novak Djokovic defeated Stanislas Wawrinka in the final, 4–6, 6–3, 6–3 to win the men's singles tennis title at the 2008 Italian Open.

Rafael Nadal was the three-time defending champion, but lost in the second round to Juan Carlos Ferrero. This marked the first of only two instances in which Nadal lost his opening match at a clay court tournament (alongside the 2024 French Open). In a six-year span from 2005 and 2010, this marked Nadal's only defeat at the event.

Seeds The top eight seeds receive a bye into the second round.

Draw

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4

Qualifying

Qualifying seeds

Qualifiers

Qualifying draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

Fifth qualifier

Sixth qualifier

Seventh qualifier

References

External links Draw Qualifying draw ITF tournament profile