The name Hiwassee is derived from the Cherokee word Ayuhwasi, meaning "savanna" or "large meadow". The name has been applied to several entities past and present in the U.S. states of Georgia, North Carolina, and Tennessee:
Bodies of water Hiwassee Lake, the reservoir created by Hiwassee Dam Hiwassee River, a tributary of the Tennessee River in northern Georgia, western North Carolina, and eastern Tennessee
Towns Ducktown, Tennessee, called Hiawassee in the 1840s–1850s Hiawassee, Georgia, a town Hiwasse, Arkansas, a town Great Hiwassee, a Cherokee village once located along the Hiwassee River in Polk County, Tennessee Hiwassee, North Carolina, a small community adjacent to Hiwassee Dam Little Hiwassee, a Cherokee village once located along the Hiwassee River in Cherokee County, North Carolina Hiwassee, Virginia, a census-designated place in Virginia
Other Hiwassee College, a college in Madisonville, Tennessee Hiwassee Dam, a hydroelectric dam on the Hiwassee River in Cherokee County, North Carolina USS Hiwassee (AOG-29), a 1944 Mettawee-class gasoline tanker