Piojo is Spanish for louse. Piojo may also refer to:
Places Rancho El Piojo, Mexican land-grant in present-day California Isla Piojo, island in the Gulf of California Piojó, a municipality and town in the Colombian department of Atlántico
People Los Piojos, Argentine rock band Miguel Herrera (born 1968), Mexican former football defender and manager known as Piojo Claudio López (footballer) (born 1974), Argentine football forward known as Piojo Roberto Alvarado (born 1998), Mexican football winger known as Piojo Piojo (footballer, born 1985), Argentine football striker Piojo (footballer, born 1989), Spanish football winger