Hypoalphalipoproteinemia (HA) is a high-density lipoprotein deficiency, inherited in an autosomal dominant manner. It can be associated with LDL receptor.

Complications Higher prevalence of heart disease and stroke have been found among patients diagnosed with HA.

Diagnosis and Treatment HDL levels below 40mg/dL define HA. Niacin is sometimes prescribed to raise HDL levels. Statin medications can also be used to increase HDL levels.

Genetics Name OMIM Locus Candidates HDLCQ1 9p ABCA1 (Tangier disease) HDLCQ2 8q23 HDLCQ3 16q24.1 Lecithin cholesterol acyltransferase deficiency (LCAT) HDLCQ4 4q32 HDLD3 11q23.3 APOA1

See also CER-001 References

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