Flye is a surname. Notable people with the surname include:
Don Flye (1933–2013), American tennis player Edwin Flye (1817–1886), American politician, merchant, banker, bank president, and shipbuilder Father James Harold Flye, Episcopal priest, history teacher, and lifelong friend and mentor of James Agee Tom Flye, drummer for Lothar and the Hand People, an American 1960s psychedelic rock band