Diagne is a Senegalese surname, and may refer to:
Abdoulaye Diagne-Faye (born 1978), Senegalese professional footballer Assane Diagne (1947–2013), Senegalese minister Blaise Diagne (1872–1934), Senegalese political leader Fama Diagne Sène (born 1969), Senegalese writer Mamadou Diagne (born 2003), Senegalese professional footballer Mbaye Diagne (1958–1994), Senegalese army officer Mbaye Diagne (footballer) (born 1991), Senegalese professional footballer Raoul Diagne (1910–2002), French football defender Souleymane Bachir Diagne (born 1955), Senegalese philosopher