Midland Hotel is the name of several English hotels. Many were former railway hotels constructed by the Midland Railway. It may refer to:
Midland Hotel, Manchester Midland Hotel, Birmingham, now managed by Macdonald Hotels as Macdonald Burlington Hotel. Midland Hotel, Bradford Midland Hotel, Derby, also known as Hallmark Hotel Derby Midland Midland Hotel, Morecambe (1933 – present) Midland Hotel, Morecambe (1871–1932), originally named North Western Hotel, Morecambe (1848–1871) Midland Grand Hotel at St Pancras station, London, now known as St Pancras Renaissance London Hotel Midland Hotel, adjacent to Mansfield railway station, Nottinghamshire The Midland Hotel, Chicago, a historic 1927 hotel in Chicago, Illinois, United States