Rothberg is a surname. Notable people with the surname include:
Bob Rothberg (1901–1938), songwriter Jonathan M. Rothberg (born 1963), American scientist and entrepreneur Justin Rothberg (born 2002), American racing driver Patti Rothberg (born 1972), American musician and artist Künter Rothberg (born 1984), Estonian judoka
See also Rothberg Institute For Childhood Diseases Roșia, Sibiu Commune, Sibiu County, Romania