John Semple may refer to: John Semple (minister) (c. 1602–c. 1677), Ulster-Scots Presbyterian minister and Scots Worthy John Semple (architect) (1801–1882), Irish architect John Semple (footballer) (1889–?), Scottish footballer Jock Semple (1903–1988), Scots-American sports official and trainer John Greenlees Semple (1904–1985), British mathematician John Semple (civil servant) (born 1940), former head of the Northern Ireland Civil Service John W. Semple (born 1959), Canadian medical researcher John C. Semple, American botanist