E3 ubiquitin-protein ligase RFFL (Ring Finger And FYVE Like Domain Containing E3 Ubiquitin) is a ubiquitin ligase enzyme that in humans is encoded by the RFFL gene. RFFL associates with endosomes. RFFL is known to affect cardiac repolarization, Cystic fibrosis transmembrane conductance regulator (CFTR) ubiquitination, and mitochondrial clearance by affecting Parkin/PRKN recruitment.
Interactors
ATXN3 MDM2 OPTN Parkin RAB10 RNF34 STUB1 VCP
See also FYVE domain RING finger domain
References
Further reading