S46 may refer to:

Submarines , of the Royal Navy , of the Indian Navy , of the United States Navy

Other uses S46 (Berlin), a line of the Berlin S-Bahn S46 (New York City bus), serving Staten Island Blériot-SPAD S.46, a French biplane airliner Explorer S-46 (satellite), a failed American spacecraft GER Class S46, a British steam locomotive Parti Melayu Semangat 46, a defunct political party in Malaysia S46: If swallowed, seek medical advice immediately and show this container or label, a safety phrase SABCA S-46, a Belgian aircraft Sulfur-46, an isotope of sulfur