SPG11

Spatacsin is a protein that in humans is encoded by the SPG11 gene.

Function Spatacsin, in combination with the SPG15 protein, attaches the AP5 adaptor complex to the outside of late Endosomes or Lysosomes when the protein via which it binds is in a particular state.

Pathology Mutations of the SPG11 gene cause a rare form of spastic paraplegia, spastic paraplegia type 11.

References

Further reading

External links GeneReviews/NCBI/NIH/UW entry on Spastic Paraplegia Type 11 SPG11-Related Hereditary Spastic Paraplegia with Thin Corpus Callosum