The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics. One speaks of two different free fractions: Plasma free fraction, previously referred to as ƒ1,Table is now referred to as ƒP according to consensus nomenclature. Tissue free fraction (ƒND), previously referred to as ƒ2
The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.
See also Binding potential
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