Pierre-Simon is a French masculine given name, and may refer to:
Pierre-Simon Ballanche (1776–1847), a French writer and counterrevolutionary philosopher Pierre Simon Fournier (1712–1768), a French typographer Pierre-Simon Girard (1765–1836), a French mathematician and engineer Pierre-Simon Laplace (1749–1827), a French mathematician and astronomer
See also Pierre Simon Pierre Simon (1885–1977)