S500 may refer to:
S-500 missile system, a Russian surface-to-air missile/anti-ballistic missile system S500, several Mercedes-Benz S-Class car models Acer CloudMobile S500, a 2012 mobile phone model BenQ S500, a 2005 mobile phone Canon PowerShot S500, a camera Fengxing S500, a car Honda S500, a 1963 car S500, a Nikon Coolpix series camera Sony Cyber-shot DSC-S500, a camera Sony Ericsson S500, a 2007 mobile phone model Yamaha PSR-S500, a portable music keyboard
See also