Eskandarian or Iskenderian is a surname. Notable people with the surname include:
Alecko Eskandarian (born 1982), Iranian-American football (soccer) player Andranik Eskandarian (born 1951), Iranian-American football (soccer) player Ed Iskenderian (1921–2026), American high performance automotive parts manufacturer Mary Ellen Iskenderian, president and CEO of Women's World Banking Vartkes Iskenderian, founder of Zankou Chicken in California