The Prince of Wales Challenge Cup is a rowing event for men's quadruple sculls at the annual Henley Royal Regatta on the River Thames at Henley-on-Thames in England. It is open to male crews from all eligible rowing clubs and has similar qualifying rules to the Ladies' Challenge Plate. Two or more clubs may combine to make an entry.

The trophy was donated to the regatta in 2007 by Mr. V. G. Saunders and was the prize awarded to the winner of the 1931 King's Cup Aero Race - E. C. T. Edwards, the brother of H. R. A. (Jumbo) Edwards.

Past winners YearWinnerRunner-UpRef 2008 California Rowing Club, U.S.A Leander Club & London Rowing Club 2009 Oxford Brookes Univ & Durham Univ Leander Club 2010 Leander Club Tideway Scullers School 2011 Leander Club Tideway Scullers School 2012 Leander Club Durham Univ & Univ of London 2013 Leander Club Aalesunds Roklub and Moss Roklubb, Norway 2014 Leander Club RTHC Bayer Leverkusen, Germany 2015 Leander Club Leander Club & Oxford Brookes Univ 2016 Schuylkill Navy, USA Leander Club A 2017 Leander Club A Leander Club B 2018 A.A.S.R. Skøll, Netherlands Edinburgh Univ & Nottingham Rowing Club 2019 Edinburgh Univ & Nottingham RC A.A.S.R. Skøll & A.U.S.R. Orca, Netherlands2020 No competition due to COVID-19 pandemic 2021 Leander Club Twickenham & Queen's University, Belfast 2022 Leander Club Reading University Boat Club 2023 Leander Club Hollandia Roeiclub, Netherlands2024Leander Club A.A.S.R. Skøll, Netherlands2025 Bonner RG e.V. and Erster Kieler RC e.V., GermanyMarlow

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