N,O-Dimethylhydroxylamine is an organic compound with the chemical formula . Its structure is . It is a colorless liquid. It is a methylated hydroxylamine used to form so called 'Weinreb amides' for use in the Weinreb ketone synthesis. It is commercially available as its hydrochloride salt (methoxy(methyl)ammonium chloride ).
Synthesis It may be prepared by reacting ethyl chloroformate (or similar) with hydroxylamine followed by treatment with a methylating agent such as dimethyl sulfate. The N,O-dimethylhydroxylamine is then liberated by acid hydrolysis followed by neutralization.
Applications Final products containing N,O-Dimethylhydroxylamine include the following: linuron, monolinuron, metobromuron, metobenzuron, chlorbromuron & sarecycline.
See also Methoxyamine N-methylhydroxylamine
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