The 1880 United States House of Representatives elections in South Carolina were held on November 2, 1880, to elect five representatives Representatives for two-year terms from the state of South Carolina. All five incumbents were re-elected and the composition of the state delegation remained solely Democratic.
1st congressional district Incumbent Democratic Congressman John S. Richardson of the 1st congressional district, in office since 1879, defeated Republican challenger Samuel J. Lee.
General election results
| colspan=5 |Democratic hold
2nd congressional district Incumbent Democratic Congressman Michael P. O'Connor of the 2nd congressional district, in office since 1879, defeated Republican challenger Edmund W.M. Mackey.
General election results
| colspan=5 |Democratic hold
3rd congressional district Incumbent Democratic Congressman D. Wyatt Aiken of the 3rd congressional district, in office since 1877, defeated Republican challenger C.J. Stollbrand.
General election results
| colspan=5 |Democratic hold
4th congressional district Incumbent Democratic Congressman John H. Evins of the 4th congressional district, in office since 1877, defeated Republican challenger A. Blythe.
General election results
| bgcolor="#0BDA51" | | Greenback-Labor | J. Hendrix McLane | align="right" | 414 | align="right" | 1.0 | align="right" | +1.0
| colspan=5 |Democratic hold
5th congressional district Incumbent Democratic Congressman George D. Tillman of the 5th congressional district, in office since 1879, defeated Republican challenger Robert Smalls.
General election results
| colspan=5 |Democratic hold
See also United States House of Representatives elections, 1880 South Carolina gubernatorial election, 1880 South Carolina's congressional districts
References "Annual Report of the Secretary of State to the General Assembly of South Carolina." Reports and Resolutions of the General Assembly of the State of South Carolina at the Regular Session of 1880. Columbia, SC: James Woodrow, 1881, pp. 553–555.