Río Sereno, also known as Sereno, is a town and corregimiento in Renacimiento District, Chiriquí Province, Panama, close to the Costa Rica border. It is the seat of Renacimiento District. It has a land area of and had a population of 5,463 as of 2010, giving it a population density of . Its population as of 1990 was 2,595; its population as of 2000 was 3,289.

It is a rural dairy and agricultural region. The town is surrounded by vegetation.

Seasons: Dry (Summer): December - April Wet (Winter): May - November

Elevation: 1000 meters (over 3200 feet)

Average temperature: 18 °C

Climate: tropical template

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