Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA).
Examples include: motexafin gadolinium. hydroxyurea fludarabine, cladribine, gemcitabine, tezacitabine, and triapine gallium maltolate, gallium nitrate<ref name="PharmRev"></ref> Tezacitabine, Tezacitabine A chemotherapy candidate nucleotide analogue that failed in clinical trials due to on-target toxicity (febrile neutropenia).
See also Ribonucleotide reductase
References
External links Ribonucleotide reductase inhibitor entry in the public domain NCI Dictionary of Cancer Terms