ESD may refer to:
Science ESD (gene), a human gene/enzyme Electrostatic discharge, a sudden flow of electricity between two electrically charged objects Electrostatic-sensitive device, any component which can be damaged by common static charges Energy spectral density, a part of a function in statistical signal processing Environmental secondary detector, a gaseous detection device used with environmental scanning electron microscopes Equivalent spherical diameter, a diameter of a sphere of equivalent volume Extreme subdwarf, a type of star
Medicine End-systolic dimension, the diameter across a ventricle in the heart Endoscopic submucosal dissection, a medical therapy with endoscopy
Education Education for sustainable development, international learning methodology Educational service district (disambiguation), regional education unit in some U.S. states Episcopal School of Dallas, day school in Texas, U.S. Evangelical School for the Deaf, in Luquillo, Puerto Rico
Government and law Electronic services delivery, government services provided through the Internet or other electronic means Empire State Development Corporation, an American public benefit umbrella organization Employment Security Department, a Washington state unemployment agency Examination support document, a submission to the United States Patent and Trademark Office
Technology Electronic smoking device, a device that simulates the feeling of smoking Electronic software distribution, delivery of digital media content ESD format, a file format Emergency shutdown, the stoppage of a process plant in certain hazardous conditions Engineering Society of Detroit, a multi-disciplinary association in Michigan, U.S. Enlightened Sound Daemon, audio software Environmentally sustainable design, complying with the principles of ecological sustainability in the design of objects and buildings
Transport Elmstead Woods railway station (station code), in London, England Esen Air (ICAO airline designator), a defunct airline from Kyrgyzstan Essendon railway station, Melbourne A US Navy hull classification symbol: Expeditionary transfer dock (ESD) Orcas Island Airport (IATA code), Eastsound on Orcas Island, Washington, United States
Other uses East Side Digital Records, an American record label Eta Sigma Delta, an American honor society