Macfarren is a surname. Notable people with the surname include:
Emma Maria Macfarren (1824–1895), English pianist and composer, sister-in-law of George Alexander Macfarren George Macfarren (1788–1843), English dramatist George Alexander Macfarren (1813–1887), English composer, son of George Macfarren Natalia Macfarren (1827–1916), singer and music translator, wife of George Alexander Macfarren Walter Cecil Macfarren (1826–1905), pianist and composer, brother of George Alexander Macfarren, and in whose name the Royal Academy of Music prize is awarded