Sanctum may refer to:
Arts and entertainment Sanctum (band), a Swedish electronic and industrial music band Sanctum (film), a 2011 Australian-American action-thriller film Sanctum (1998 video game), a digital collectible card game Sanctum (2011 video game), a first-person shooter tower defense video game
Other uses Sanctum Inc., an American information technology company focused on application security
See also Garbhagriha, the innermost sanctuary of Hindu, Jain, and Buddhist temples Sanctum sanctorum, a Latin phrase meaning "Holy of Holies" Sanctum Sanctorum (Marvel Comics), a fictional building in the Marvel Universe