Lye is a caustic chemical, usually referring to sodium hydroxide.

Lye or LYE may also refer to: Places Lye, West Midlands, a town in England Lye, Indre, a commune of the Indre département in France Lye railway station, England, whose National Rail station code is LYE RAF Lyneham, a former Royal Air Force station in Wiltshire, England whose IATA code is LYE

People Edward Lye (1694–1767), English scholar Len Lye (1901–1980), New Zealand-born artist James Lye, Singaporean actor Kåre Arnstein Lye (1940–2021), Norwegian botanist See also Lje