Kirksville is an unincorporated community located in Madison County, Kentucky, United States. It was formerly known as Centerville; the new name honored local store owner Samuel Kirkendall.Rennick, Robert. Kentucky Place Names, p. 161. University Press of Kentucky (Lexington), 1987. Accessed 1 August 2013. It is located at the junction of Kentucky Route 595 and Kentucky Route 1295.
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