Big Knife may refer to:

The Big Knife, 1955 American film The Big Knife (play), 1949 American play by Clifford Odets Big Knife Provincial Park, a small provincial park in central Alberta, Canada Osla Big Knife, an Anglo-Saxon King of Kent, 6th century Sami knife, a long, wide blade traditionally used by the Sami people

See also Big Knives The Small Knives