Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene. This protein is one of the 4 subunits in the Gi/o family of G-proteins. These subunits play an important role in inhibitory signaling for G protein-coupled receptors. Variants in this gene are associated with Auriculocondylar Syndrome 1, a rare syndrome which often involves atypical ear and/or facial features and developmental delays.
Interactions
GNAI3 has been shown to interact with:
RGS10 RGS12, RGS14, RGS16, RGS18, RGS19, RGS5, RIC8A, and S1PR1.
See also Gi alpha subunit
References
Further reading