TiHKAL: The Continuation, also known as Tryptamines I Have Known and Loved, is a 1997 book written by Alexander Shulgin and Ann Shulgin. It is about a family of psychoactive drugs known as tryptamines, which includes psychedelics, other hallucinogens, and entactogens. The book has two halves, and the second part of the book contains detailed entries on 55tryptamines. TiHKAL is a sequel to PiHKAL: A Chemical Love Story (Phenethylamines I Have Known and Loved) (1991).
Content TiHKAL, much like its predecessor PiHKAL, is divided into two parts. The first part, for which all rights are reserved, begins with a fictionalized autobiography, picking up where the similar section of PiHKAL left off; it then continues with a collection of essays on topics ranging from psychotherapy and the Jungian mind to the prevalence of DMT in nature, ayahuasca and the war on drugs.
The second part of TiHKAL, which may be conditionally distributed for non-commercial reproduction , is a detailed synthesis manual for 55tryptamines (many discovered by Alexander Shulgin himself), including their chemical structures, doses, durations, and commentary. It includes entries on compounds including simple tryptamines like dimethyltryptamine (DMT), psilocin, and 5-MeO-DMT, α-alkyltryptamines like α-methyltryptamine (AMT), β-carbolines or harmala alkaloids like harmaline, the iboga alkaloid ibogaine, and lysergamides like LSD. Whereas PiHKAL had 179entries on phenethylamines, TiHKAL has only 55entries. Shulgin has made the second part freely available on Erowid while the first part is available only in the printed text.
Members of the Shulgin research group who contributed to the experience reports included Shulgin himself, Ann Shulgin, Myron Stolaroff, Jean Stolaroff, Darrell Lemaire, and Peyton Jacob III, among others.
Shulgin corresponded with the Temple of the True Inner Light, a psychedelic church based in New York City that was founded in 1980 and employed dipropyltryptamine (DPT) as its sacrament for decades, and wrote briefly but kindly about them in the chapter on DPT in TiHKAL.
Response As with PiHKAL, the Shulgins were motivated to release the synthesis information as a way to protect the public's access to information about psychedelic compounds, a goal Alexander Shulgin has noted many times. Following a raid of his laboratory in 1994 by the United States DEA, Richard Meyer, spokesman for DEA's San Francisco Field Division, stated that "It is our opinion that those books [referring to the previous work, PiHKAL] are pretty much cookbooks on how to make ‘controlled drugs’. Agents tell me that in clandestine labs that they have raided, they have found copies of those books."
Notable compounds Some compounds in TiHKAL, including dimethyltryptamine (DMT), psilocybin (4-PO-DMT), psilocin (4-HO-DMT), bufotenin (5-HO-DMT), 5-MeO-DMT, α-methyltryptamine (AMT), lysergic acid diethylamide (LSD), harmaline, and ibogaine, are widely known and/or used hallucinogens.
Tryptamines listed
# Substance Chemical name Group Dosea Duration Link 1 AL-LAD (6-allyl-6-nor-LSD) 6-Allyl-N,N-diethyl-NL Lysergamide 80–160 μg 6–8 hours 2 DBT (dibutyltryptamine) N,N-Dibutyl-T Tryptamine Unknown Unknown 3 DET (diethyltryptamine) N,N-Diethyl-T Tryptamine 50–100 mg 2–4 hours 4 DiPT (diisopropyltryptamine) N,N-Diisopropyl-T Tryptamine 25–100 mg 6–8 hours 5 α,O-DMS (5-MeO-AMT) 5-Methoxy-α-methyl-T α-Alkyltryptamine 2.5–4.5 mg 12–18 hours 6 DMT (dimethyltryptamine) N,N-Dimethyl-T Tryptamine Variousb Up to 1 hour 7 2,α-DMT (2-methyl-AMT) 2,α-Dimethyl-T α-Alkyltryptamine 300–500 mg 7–10 hours 8 α,N-DMT (N-methyl-AMT) α,N-Dimethyl-T α-Alkyltryptamine 50–100 mg 6–8 hours 9 DPT (dipropyltryptamine) N,N-Dipropyl-T Tryptamine 100–250 mg 2–4 hours 10 EiPT (ethylisopropyltryptamine) N-Ethyl-N-isopropyl-T Tryptamine 24–40 mg 4–6 hours 11 α-ET (AET; α-ethyltryptamine) α-Ethyl-T α-Alkyltryptamine 100–150 mg 6–8 hours 12 ETH-LAD (6-ethyl-6-nor-LSD) 6,N,N-Triethyl-NL Lysergamide 40–150 μg 8–12 hours 13 Harmaline (dihydroharmine) 3,4-Dihydro-7-methoxy-1-methyl-BC β-Carboline 150–300 mg 5–8 hours 14 Harmine 7-Methoxy-1-methyl-BC β-Carboline >300 mg Unknown 15 4-HO-DBT N,N-Dibutyl-4-hydroxy-T 4-Hydroxytryptamine >20 mg Unknown 16 4-HO-DET N,N-Diethyl-4-hydroxy-T 4-Hydroxytryptamine 10–25 mg 4–6 hours 17 4-HO-DiPT N,N-Diisopropyl-4-hydroxy-T 4-Hydroxytryptamine 15–20 mg 2–3 hours 18 4-HO-DMT (psilocin) N,N-Dimethyl-4-hydroxy-T 4-Hydroxytryptamine 10–20 mg 3–6 hours 19 5-HO-DMT (bufotenin) N,N-Dimethyl-5-hydroxy-T 5-Hydroxytryptamine 8–16 mg 1–2 hours 20 4-HO-DPT N,N-Dipropyl-4-hydroxy-T 4-Hydroxytryptamine Unknown Unknown 21 4-HO-MET N-Ethyl-4-hydroxy-N-methyl-T 4-Hydroxytryptamine 10–20 mg 4–6 hours 22 4-HO-MiPT 4-Hydroxy-N-isopropyl-N-methyl-T 4-Hydroxytryptamine 12–25 mg 4–6 hours 23 4-HO-MPT 4-Hydroxy-N-methyl-N-propyl-T 4-Hydroxytryptamine Unknown Unknown 24 4-HO-pyr-T 4-Hydroxy-N,N-tetramethylene-T Pyrrolidinylethylindole >20 mg Unknown 25 Ibogaine A complexly substituted-T Azepinoindole Variousc "Quite long" 26 LSD (METH-LAD) N,N-Diethyl-L Lysergamide 60–200 μg 8–12 hours 27 MBT (methylbutyltryptamine) N-Butyl-N-methyl-T Tryptamine 250–400 mg 4–6 hours 28 4,5-MDO-DiPT N,N-Diisopropyl-4,5-methylenedioxy-T Other >25 mg Unknown 29 5,6-MDO-DiPT N,N-Diisopropyl-5,6-methylenedioxy-T Other Unknown Unknown 30 4,5-MDO-DMT N,N-Dimethyl-4,5-methylenedioxy-T Other Unknown Unknown 31 5,6-MDO-DMT N,N-Dimethyl-5,6-methylenedioxy-T Other >5 mg Unknown 32 5,6-MDO-MiPT N-Isopropyl-N-methyl-5,6-methylenedioxy-T Other >50 mg Unknown 33 2-Me-DET (2-methyl-DET) N,N-Diethyl-2-methyl-T Other 80–120 mg 6–8 hours 34 2-Me-DMT (2-methyl-DMT) 2,N,N-Trimethyl-T Other 50–100 mg 4–6 hours 35 Melatonin (5-MeO-NAcT) N-Acetyl-5-methoxy-T N-Acetyltryptamine 1–10 mg "A few hours" 36 5-MeO-DET N,N-Diethyl-5-methoxy-T 5-Methoxytryptamine 1–3 mg 3–4 hours 37 5-MeO-DiPT N,N-Diisopropyl-5-methoxy-T 5-Methoxytryptamine 6–12 mg 4–8 hours 38 5-MeO-DMT 5-Methoxy-N,N-dimethyl-T 5-Methoxytryptamine Variousd 1–2 hours 39 4-MeO-MiPT N-Isopropyl-4-methoxy-N-methyl-T Other 20–30 mg 4–6 hours 40 5-MeO-MiPT N-Isopropyl-5-methoxy-N-methyl-T 5-Methoxytryptamine 4–6 mge 4–6 hours 41 5,6-MeO-MiPT 5,6-Dimethoxy-N-isopropyl-N-methyl-T Other >75 mg Unknown 42 5-MeO-NMT 5-Methoxy-N-methyl-T 5-Methoxytryptamine Unknown Unknown 43 5-MeO-pyr-T 5-Methoxy-N,N-tetramethylene-T Pyrrolidinylethylindole 0.5–2 mg "Several hours" 44 6-MeO-THH 6-Methoxy-1-methyl-1,2,3,4-tetrahydro-BC β-Carboline Unknown Unknown 45 5-MeO-TMT 5-Methoxy-2,N,N-trimethyl-T Other 75–150 mg 5–10 hours 46 5-MeS-DMT N,N-Dimethyl-5-methylthio-T Other 15–30 mg <1 hour 47 MiPT (methylisopropyltryptamine) N-Isopropyl-N-methyl-T Tryptamine 10–25 mg 3–4 hours 48 α-MT (AMT; α-methyltryptamine) α-Methyl-T α-Alkyltryptamine 15–30 mgf 12–16 hours 49 NET (N-ethyltryptamine) N-Ethyl-T Tryptamine Unknown Unknown 50 NMT (N-methyltryptamine) N-Methyl-T Tryptamine Unknown Unknown 51 PRO-LAD (6-propyl-6-nor-LSD) 6-Propyl-NL Lysergamide 100–200 μg 6–8 hours 52 pyr-T (pyrrolidinyltryptamine) N,N-Tetramethylene-T Pyrrolidinylethylindole Unknown Unknown 53 T (tryptamine) Tryptamine Tryptamine 250 mg "Very short" 54 Tetrahydroharmine (THH) 7-Methoxy-1-methyl-1,2,3,4-tetrahydro-BC β-Carboline 300 mg Unknown 55 α,N,O-TMS (5-MeO-α,N-DMT) α,N-Dimethyl-5-methoxy-T α-Alkyltryptamine 10–20 mg 6–8 hours 56 5-MeO-DALTg 5-Methoxy-N,N-diallyl-T 5-Methoxytryptamine 12–20 mg 2–4 hours 57 DALT (diallyltryptamine)g N,N-Diallyl-T Tryptamine >40 mg Unknown Acronyms (in chemical names): T = tryptamine; BC = β-carboline; L = lysergamide; NL = 6-norlysergamide. Footnotes: a = Dose and duration for compounds are orally unless otherwise specified. b = DMT doses are >350mg orally, 60–100mg intramuscularly, subcutaneously, or smoked, and 4–30mg intravenously. c = Ibogaine dose is "from hundreds of [mg] up to [1g] or more". d = 5-MeO-DMT doses are 6–20mg smoked and 2–3 mg intravenously. e = 5-MeO-MiPT doses are 4–6mg orally and 12–20mg smoked. f = AMT doses are 15–30 mg orally and 5–20 mg smoked. g = The 5-MeO-DALT (#56) and DALT (#57) entries were not included in the published version of TiHKAL and were subsequently released in 2004.
In addition to TiHKAL, Shulgin has also described the properties of psychedelic tryptamines in humans in literature reviews.
See also Bibliography of Alexander Shulgin PiHKAL (Phenethylamines I Have Known and Loved) (1991) The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds (2011) List of psychedelic literature Substituted tryptamine Substituted β-carboline and harmala alkaloid Azepinoindole and iboga alkaloid Substituted lysergamide
References
External links
Erowid Online Books: TiHKAL: The Continuation by Alexander & Ann Shulgin "Shulgin in Spanish" Project – Information on the first complete translation of PiHKAL and TiHKAL into Spanish TiHKAL • Info: A Visual Index and Map of TiHKAL: The Continuation by Alexander & Ann Shulgin Transform Press – Publisher of TiHKAL TiHKAL - Wikipedia Massviews Analysis (Wikipedia Page Views of Individual TiHKAL Entries)