Bethke is a surname. Notable people with the surname include:
Andrew-John Bethke, South African composer Arap Bethke (born 1980), Mexican actor Bruce Bethke (born 1955), American author Des Bethke (born 1943), Australian rules footballer Erik Bethke (born 1972), American computer games developer Ingo, Holger and Egbert Bethke, who escaped from East Germany Jean Bethke Elshtain (1941–2013), American political philosopher Katie Bethke (born 1988), American soccer player Michael Bethke, American murderer Penny Bethke (1950–2011), Canadian co-operative business leader Sigfried Bethke (born 1954), German physicist