Lusignan can refer to:
Lusignan dynasty, a European ruling family Château de Lusignan, the seat of the lords of Lusignan in Lusignan, Vienne, France Lusignan, Vienne, a town in Vienne, France Canton of Lusignan, a canton in Vienne, France Lusignan-Petit, a town in Lot-et-Garonne, France Lusignan, Guyana, a town in Guyana. Franz Joseph, Marquis de Lusignan, an Austrian general (1753-1832)