S48 may refer to:
Aviation Blériot-SPAD S.48, a French biplane airliner Country Squire Airpark in Clackamas County, Oregon, United States SABCA S-48, a Belgian aircraft Sikorsky S-48, an American helicopter
Other uses S48 (New York City bus) serving Staten Island County Route S48 (Bergen County, New Jersey) , a submarine of the Royal Navy S48: Keep wet with ... (appropriate material to be specified by the manufacturer), a safety phrase , a submarine of the United States Navy