Comencini () is an Italian surname from Lombardy and Veneto, originally indicating people from the area of Lake Como (particularly Comacine masters). Notable people with the surname include:
Cristina Comencini (born 1956), Italian film director, scriptwriter and novelist, daughter of Luigi Fabrizio Comencini (born 1953), Italian Venetist politician Francesca Comencini (born 1961), Italian film director and screenwriter, daughter of Luigi Luigi Comencini (1916–2007), Italian film director