Lepenica, Serbia may refer to several places:

Lepenica (Great Morava), a river in Šumadija district Lepenica (region) Lepenica (Vladičin Han), a village in the municipality of Vladičin Han, Pčinja District Lepenica, Pčinja, a village in Pčinja District Lepenica, Mačva, a village in Mačva District